CLINICAL - Homeopathic medical studies

1: Homeopathy. 2004 Oct;93(4):179-85.Links

Comment in:

Homeopathy. 2004 Oct;93(4):171-2.

Homeopathy. 2005 Jan;94(1):69; author reply 69-70.

Homeopathic proving symptoms: result of a local, non-local, or placebo process? A blinded, placebo-controlled pilot study.

Walach H, Sherr J, Schneider R, Shabi R, Bond A, Rieberer G.

Department of Evaluation Research in Complementary Medicine, Samueli Institute--European Office, Institute for Environmental Medicine and Hospital Epidemiology, University Hospital Freiburg, Germany.

BACKGROUND: Homeopathic pathogenetic trials (HPTs) (provings) are the pillar of homeopathy. Symptoms experienced by healthy volunteers are used to find the correct medicine for therapy. It is unclear whether these symptoms are specific or due to placebo noise. Furthermore, it is uncertain whether proving effects, if present at all, are due to a local or non-local process OBJECTIVES: To develop a test model which allows for testing if homeopathic proving symptoms are caused by placebo or causative mechanisms, and if these symptoms are due to local or non-local processes. DESIGN: Randomised, blinded, placebo-controlled, parallel-group study, with 1-week baseline and 2-weeks proving period. SUBJECTS: 11 healthy volunteers from two different homeopathic schools. PROVING SUBSTANCE: An homeopathic medicine (Cantharis 30c), blindly chosen from 12 potential medicines, compared to placebo. OUTCOME MEASURE: Number of symptoms typical for the medicine in the experimental and control group during baseline and proving period. RESULTS: During baseline there was no difference in the number of typical or atypical symptoms in either group. During the proving period, both more typical symptoms for Cantharis (P= 0.03) and more atypical symptoms (P= 0.02) were observed compared to baseline. Between-group differences were not significant. Effect sizes for the difference between the proving and control group for typical symptoms was d=0.4, and for atypical symptoms d=0.6. DISCUSSION: This proving model could be valuable in studying the validity of proving symptoms of homeopathic substances in healthy volunteers. CONCLUSION: Homeopathic proving symptoms appear to be specific to the medicine and do not seem to be due to a local process. Since this was a pilot study using a small number of provers, rival hypotheses cannot be ruled out and the study needs replication.

PMID: 15532695 [PubMed - indexed for MEDLINE]$=relatedarticles&logdbfrom=pubmed

1: Homeopathy. 2005 Jul;94(3):164-74.Links

Classical and new proving methodology: provings of Plumbum metallicum and Piper methysticum and comparison with a classical proving of Plumbum metallicum.

Signorini A, Lubrano A, Manuele G, Fagone G, Vittorini C, Boso F, Vianello P, Rebuffi A, Frongia T, Rocco V, Pichler C.

FIAMO Scientific Department (1994 2004), Verona, Italy.

OBJECTIVE: To study the reliability of a proving methodology and the reproducibility of proving symptoms. METHODS: Two homeopathic medicines and placebo were given, in a double-blind randomized design, to 31 healthy volunteers (13 Piper methysticum 30C, 11 placebo and 7 Plumbum metallicum 30C), 5 drops 4 times daily, until the onset of unbearable symptoms, or at most for 1 week. The primary outcome measure was the number of phrases containing unusual or new symptoms selected by supervisors (SEL) from unstructured diaries and the number of these symptoms (SYM) present in SELs. The secondary outcome measures were the number of symptoms with modalities of both verum groups concordant with symptoms reported in a previous proving of Plumbum 12C. Other parameters evaluated were repeated and crossed symptoms in SELs. RESULTS: Both medicines showed qualitative and quantitative differences from placebo. Piper: 146 SELs (median: 5), Plumbum: 118 SELs (16), placebo: 48 SELs (2), containing 260 (8), 199 (29) and 58 (2) SYMs, respectively. There was a significant difference from placebo in Plumbum but not in Piper SELs and SYMs (P < 0.05). 31, 24 and 4 'repeated' and 18, 22 and 2 'crossed' symptoms were found in Piper, Plumbum and placebo. 8 and 30 symptoms concordant with the classical proving of Plumbum were found for Piper and Plumbum, corresponding to about 10% and 45% of their total SELs. CONCLUSIONS: Open diaries, supervision and double-blind placebo are useful methods in homeopathic pathogenetic trials. Estimates of concordance should be introduced in proving methodology.

PMID: 16060202 [PubMed - indexed for MEDLINE]$=relatedarticles&logdbfrom=pubmed

Double-blind, placebo-controlled homeopathic pathogenetic trials: symptom collection and analysis.

Dominici G, Bellavite P, di Stanislao C, Gulia P, Pitari G.

Centro Omeopatico Vescovio, p.zza Vescovio 7, Rome, Italy.

BACKGROUND: Homeopathic pathogenetic trials (provings) are fundamental to homeopathy. Since most of the data from available provings have not been statistically evaluated, it is unclear how specific reported symptoms are and how they differ from those reported by people taking placebo. METHOD: We combine and analyse data from two different homeopathic pathogenic trials--including 10 and 11 provers, respectively, and both including 30% placebo-to test the null hypothesis that there is no significant difference between the number of symptoms in placebo and verum groups. RESULTS: The principal results were: Placebo reported less symptoms than verum groups. Symptom distribution according to predefined classes (common symptoms increased in intensity and/or duration-, cured, old, new and exceptional) was statistically different between placebo and verum group at a high level of significance (P<0.001). Compared to verum, placebo provers reported less new and old but more common (increased in duration or intensity) symptoms. Within repertory categories, other differences were detected. The two groups differ in terms of the duration of each symptom and kinetics of symptoms: most symptoms were more persistent in verum than in placebo groups and verum provers recorded a decreasing number of symptoms with time. Placebo provers did not show such a temporal pattern. CONCLUSIONS: If confirmed by other studies these results would demonstrate the non-equivalence between homeopathic medicines in high dilution and placebo and contribute to the improvement of proving methodology and evaluation.

PMID: 16815514 [PubMed - indexed for MEDLINE]$=relatedarticles&logdbfrom=pubmed


1: Forsch Komplementmed. 2009 Apr;16(2):105-10. Epub 2009 Apr 9. Links

Homeopathic pathogenetic trials produce specific symptoms different from placebo.

Mollinger H, Schneider R, Walch H

Department of Human Sciences, University of Osnabrück, Germany.

Introduction: Homeopathy uses information gathered from healthy volunteers taking homeopathic substances (pathogenetic trials) for clinical treatment. It is controversial whether such studies produce symptoms different from those produced by placebo. Objective: To test whether homeopathic preparations produce different symptoms than placebo in healthy volunteers. Methods: Three armed, double-blind, placebo controlled randomised experimental pathogenetic study in 25 healthy volunteers who took either one of two homeopathic remedies, Natrum muriaticum and Arsenicum album in 30CH or identical placebo. Main outcome parameter was the number of remedy-specific symptoms per group. Results: On average, 6 symptoms typical for Arsenicum album were experienced by participants taking arsenicum album, 5 symptoms typical for Natrum muriaticum by those taking natrum muriaticum, and 11 non-specific symptoms by those in the placebo group. Differences were significant overall (Kruskall Wallis test, p = 0.0002,) and significantly different from placebo (Mann-Whitney test, p = 0.001). Conclusion: Homeopathic remedies produce different symptoms than placebo. Copyright (c) 2009 S. Karger AG, Basel.

Anthroposophic medical therapy in chronic disease: a four-year prospective cohort study.

Hamre HJ, Witt CM, Glockmann A, Ziegler R, Willich SN, Kiene H.

Institute for Applied Epistemology and Medical Methodology, Freiburg, Germany.

The purpose of this study was to describe clinical outcomes in patients with chronic diseases treated by anthroposophic physicians after an initial prolonged consultation.$=relatedarticles&logdbfrom=pubmed


WITT: Homeopathic medical practice: long-term results of a cohort study with 3981 patients.

Witt CM, Lüdtke R, Baur R, Willich SN.

Institute for Social Medicine, Epidemiology and Health Economics, Charité University Medical Center, D-10098 Berlin, Germany

WITT: How healthy are chronically ill patients after eight years of homeopathic treatment?--Results from a long term observational study.

Witt CM, Lüdtke R, Mengler N, Willich SN.$=citedinpmcarticles&logdbfrom=pubmed

PEDIATRICS: Homeopathic treatment of children with attention deficit hyperactivity disorder: a randomised, double blind, placebo controlled crossover trial. Eur J Pediatr. 2007 May;166(5):509.

Frei H, Everts R, von Ammon K, Kaufmann F, Walther D, Hsu-Schmitz SF, Collenberg M, Fuhrer K, Hassink R, Steinlin M, Thurneysen A.$=relatedarticles&logdbfrom=pubmed





Complementary and alternative medical (CAM) therapies used by children with cancer treated at an Italian pediatric oncology unit.

Clerici CA, Veneroni L, Giacon B, Mariani L, Fossati-Bellani F.

Pediatr Blood Cancer. 2009 Jun 2. [Epub ahead of print]

Pediatric Oncology Unit, Fondazione IRCCS Istituto Nazionale Tumori, Milan, Italy.

Edited abstract: This study showed the prevalence of CAM usage at an Italian pediatric oncology department, and why patients used them. Parents whose children were treated at the Istituto Nazionale Tumori in Milano were surveyed: 12.4% of the children used at least one type of CAM and homoeopathy was the most often used. 83% reported benefits.

Ruta 6 selectively induces cell death in brain cancer cells but

proliferation in normal peripheral blood lymphocytes:

A novel treatment for human brain cancer




Departments of 1Cancer Biology and 2Laboratory Medicine, The University of Texas M.D. Anderson Cancer Center,

Houston, TX 77030, USA; 3PBH Research Foundation, 10/3/1 Elgin Road, Kolkata 700 020, West Bengal, India

Effect of Homeopathic Medicines on Transplanted Tumors in


ES Sunila, Girija Kuttan, Preethi KC, Ramadasan Kuttan*

Asian Pacific J Cancer Prev, 8, 390-394


Can homeopathic treatment slow prostate cancer growth?

Jonas WB, Gaddipati JP, Rajeshkumar NV, Sharma A, Thangapazham RL, Warren J, Singh AK, Ives JA, Olsen C, Mog SR, Maheshwari RK.

Samueli Institute, 1700 Diagonal Road, Suite 400, Alexandria, VA

Effects of homeopathic preparations on human prostate cancer growth in cellular and animal models.

Integr Cancer Ther. 2006 Dec;5(4):362-72

Department of Physiology and Biophysics, Georgetown University Medical Center, Washington, DC 20007, USA.

Dynamized Preparations in Cell Culture

Ellanzhiyil Surendran Sunila, Ramadasan Kuttan, Korengath Chandran Preethi and Girija Kuttan

Amala Cancer Research Centre, Amala Nagar, Thrissur, Kerala–680 555, India

Although reports on the efficacy of homeopathic medicines in animal models are limited, there are even fewer reports on the in vitro action of these dynamized preparations. We have evaluated the cytotoxic activity of 30C and 200C potencies of ten dynamized medicines against Dalton's Lymphoma Ascites, Ehrlich's Ascites Carcinoma, lung fibroblast (L929) and Chinese Hamster Ovary (CHO) cell lines and compared activity with their mother tinctures during short-term and long-term cell culture. The effect of dynamized medicines to induce apoptosis was also evaluated and we studied how dynamized medicines affected genes expressed during apoptosis. Mother tinctures as well as some dynamized medicines showed significant cytotoxicity to cells during short and long-term incubation. Potentiated alcohol control did not produce any cytotoxicity at concentrations studied. The dynamized medicines were found to inhibit CHO cell colony formation and thymidine uptake in L929 cells and those of Thuja, Hydrastis and Carcinosinum were found to induce apoptosis in DLA cells. Moreover, dynamized Carcinosinum was found to induce the expression of p53 while dynamized Thuja produced characteristic laddering pattern in agarose gel electrophoresis of DNA. These results indicate that dynamized medicines possess cytotoxic as well as apoptosis-inducing properties.

Keywords: apoptosis – cytotoxicity – p53 – thymidine uptake

Outcomes from homeopathic prescribing in medical practice: A prospective, research-targeted, pilot study

RT Mathie and TW Robinson

Faculty of Homeopathy and British Homeopathic Association, Hahnemann House, 29 Park Street West, Luton, LU1 3BE, UK

A pilot data collection study, in which 14 homeopathic dentists collected clinical and outcome

data over a 6-month period in their practice setting.

Heel Engystol N influenza study

A combination Injection Preparation as a Prophylactic for Flu and Common colds